Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 9/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209936 | 0.95 | HSD11B1 (0.50) | CACNA1HHSD11B1TRPV1 | |
| SCHEMBL8201876 | 0.84 | CACNA1H (0.51) | CACNA1HHSD11B1TRPV1 | |
| SCHEMBL8202542 | 0.83 | CACNA1H (0.59) | CACNA1HTRPV1 | |
| SCHEMBL8210399 | 0.82 | TRPV1 (0.59) | CACNA1HTRPV1 | |
| SCHEMBL8210895 | 0.82 | CACNA1H (0.68) | CACNA1HTRPV1 | |
| SCHEMBL8210396 | 0.82 | TRPV1 (0.66) | CACNA1HTRPV1 | |
| SCHEMBL8210596 | 0.81 | CACNA1H (0.55) | CACNA1HTRPV1 | |
| SCHEMBL8210273 | 0.81 | TRPV1 (0.54) | CACNA1HTRPV1 | |
| SCHEMBL8212614 | 0.81 | TP53 (0.55) | CACNA1HTRPV1NPC1L1 | |
| SCHEMBL8202447 | 0.80 | CACNA1H (0.54) | CACNA1HTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033464-A2 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF DISORDERS OF THE LIPID METABOLISM | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |