Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.57 |
| ▸ | HTR1B | P28222 | 5/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | HTR1F | P30939 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205314 | 0.89 | HTR1D (0.62) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8205310 | 0.89 | HTR1D (0.62) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4673580 | 0.83 | HTR1B (0.71) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8187195 | 0.83 | HTR1D (0.60) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8209801 | 0.81 | HTR1D (0.58) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7013891 | 0.80 | HTR1D (0.66) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8915078 | 0.79 | CYP1A2 (0.61) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8915068 | 0.79 | CYP1A2 (0.61) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8915073 | 0.79 | CYP1A2 (0.61) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9764575 | 0.78 | MAPT (0.63) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000000490-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |