Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.49 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PAM | P19021 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27802061 | 0.84 | ANPEP (0.52) | ANPEPRNPEPDNPEPLARS1LTA4H | |
| SCHEMBL4414630 | 0.84 | TSHR (0.59) | TSHRALDH1A1MAPK1L3MBTL1PAM | |
| SCHEMBL208390 | 0.83 | ANPEP (0.57) | ANPEPRNPEPDNPEPLTA4HSLC7A5 | |
| SCHEMBL8740769 | 0.83 | ALDH1A1 (0.51) | TSHRALDH1A1MAPK1L3MBTL1PAM | |
| SCHEMBL15532005 | 0.83 | SLC7A5 (0.58) | TSHRALDH1A1MAPK1L3MBTL1PAM | |
| SCHEMBL7460011 | 0.81 | ANPEP (0.48) | ANPEPRNPEPDNPEPALDH1A1 | |
| SCHEMBL6864986 | 0.81 | ANPEP (0.48) | ANPEPRNPEPDNPEPALDH1A1 | |
| SCHEMBL16439989 | 0.80 | TSHR (0.68) | TSHRALDH1A1MAPK1L3MBTL1PAM | |
| SCHEMBL8644205 | 0.80 | TSHR (0.54) | TSHRALDH1A1MAPK1L3MBTL1PAM | |
| SCHEMBL17458666 | 0.80 | ALDH1A1 (0.49) | TSHRALDH1A1MAPK1L3MBTL1PAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6033823-A | Mutated penicillin G acylase genes | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V., (NL) | 2000-03-07 | — | — | US | disclosed |
| EP-0775210-B1 | MUTATED PENICILLIN G ACYLASE GENES | DSM NV (NL) | 2000-02-02 | — | — | EP | disclosed |
| US-5935831-A | MUTATIONS IN AMINO ACID SEQUENCE OF ACYLASE RESULT IN ALTERATED SUBSTRATE SPECIFICITY; FOR ACYLATION OR DEACYLATION OF CEPHALOSPORIN AND PENICILLIN ANTIBIOTICS | GIST-BROCADES, N.V. (NL) | 1999-08-10 | — | — | US | disclosed |
| US-5891703-A | Mutated penicillin G acylase genes | GIST-HROCADES (NL) | 1999-04-06 | — | — | US | disclosed |
| EP-0453048-B1 | Mutated beta-lactam acylase genes | GIST BROCADES NV (NL) | 1998-06-17 | — | — | EP | disclosed |
| US-5695978-A | CULTURE PRODUCT | GIST-BROCADES, N.V. (NL) | 1997-12-09 | — | — | US | disclosed |
| EP-0775210-A1 | MUTATED PENICILLIN G ACYLASE GENES | GIST-BROCADES B.V. (NL) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005318-A1 | MUTATED PENICILLIN G ACYLASE GENES | GIST-BROCADES B.V. (NL) | 1996-02-22 | — | — | WO | disclosed |
| US-5457032-A | Having altered substrate specificity | GIST-BROCADES NV (NL) | 1995-10-10 | — | — | US | disclosed |
| EP-0453047-B1 | Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme | GIST BROCADES NV (NL) | 1995-07-05 | — | — | EP | disclosed |
| US-5168048-A | Genetic engineering of Alcaligenes | GIST-BROCADES NV (NL) | 1992-12-01 | — | — | US | disclosed |
| WO-1991016435-A1 | MUTATED BETA-LACTAM ACYLASE GENES | GIST-BROCADES N.V. (NL) | 1991-10-31 | — | — | WO | disclosed |
| EP-0453048-A1 | Mutated beta-lactam acylase genes | GIST-BROCADES N.V. (NL) | 1991-10-23 | — | — | EP | disclosed |
| EP-0453047-A1 | Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme | GIST-BROCADES N.V. (NL) | 1991-10-23 | — | — | EP | disclosed |