SCHEMBL8740769

SCHEMBL8740769

N[C@@H](CO)C(=O)OC(=O)Cc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.51
MAPK1 P28482 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
PAM P19021 1/20 0.50
TSHR P16473 1/20 0.49
SLC7A5 Q01650 2/20 0.44
ALPI P09923 1/20 0.44
PKM P14618 1/20 0.44
PTGS1 P23219 1/20 0.44
XIAP P98170 1/20 0.44
PRKCA P17252 1/20 0.44
PRKCD Q05655 1/20 0.44
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
AKR1B1 P15121 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
KMT2A Q03164 1/20 0.41
ADRB2 P07550 1/20 0.40
ADRB1 P08588 1/20 0.40
ADRB3 P13945 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17458666 0.87 ALDH1A1 (0.49) ALDH1A1MAPK1L3MBTL1PAMTSHR
SCHEMBL15532005 0.87 SLC7A5 (0.58) ALDH1A1MAPK1L3MBTL1PAMTSHR
SCHEMBL8210229 0.83 TSHR (0.53) ALDH1A1MAPK1L3MBTL1PAMTSHR
SCHEMBL402494 0.81 L3MBTL1 (0.46) ALDH1A1MAPK1L3MBTL1PAMTSHR
SCHEMBL1702340 0.81 ALDH1A1 (0.46) ALDH1A1MAPK1L3MBTL1PAMTSHR
SCHEMBL2494942 0.81 SLC7A5 (0.59) SLC7A5ALPIPKMPTGS1XIAP
SCHEMBL21495214 0.81 SLC7A5 (0.59) SLC7A5ALPIPKMPTGS1XIAP
SCHEMBL4414630 0.81 TSHR (0.59) ALDH1A1MAPK1L3MBTL1PAMTSHR
SCHEMBL9554894 0.80 SLC7A5 (0.55) ALDH1A1MAPK1L3MBTL1PAMTSHR
SCHEMBL3340704 0.80 L3MBTL1 (0.45) ALDH1A1MAPK1L3MBTL1PAMTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0785768-A4 1997-07-30 EP claimed
EP-0785768-A1 O-ACYL SERINES AS DEODORANTS THE GILLETTE COMPANY (US) 1997-07-30 EP claimed
WO-1995007069-A1 O-ACYL SERINES AS DEODORANTS THE GILLETTE COMPANY (US) 1995-03-16 WO claimed
EP-0785768-A4 1997-07-30 EP disclosed
EP-0785768-A1 O-ACYL SERINES AS DEODORANTS THE GILLETTE COMPANY (US) 1997-07-30 EP disclosed
WO-1995007069-A1 O-ACYL SERINES AS DEODORANTS THE GILLETTE COMPANY (US) 1995-03-16 WO disclosed