Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | HTR7 | P34969 | 4/20 | 0.69 |
| ▸ | HTR1A | P08908 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ME2 | P23368 | 1/20 | 0.58 |
| ▸ | ME1 | P48163 | 1/20 | 0.58 |
| ▸ | ME3 | Q16798 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30528252 | 0.90 | MAPT (0.86) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL6388426 | 0.86 | MAPT (0.70) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL28135156 | 0.85 | MAPT (0.78) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL27786793 | 0.85 | MAPT (0.78) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL9988385 | 0.83 | MAPT (0.76) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL12282092 | 0.83 | MAPT (0.76) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL13080422 | 0.82 | MAPT (0.84) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL7840682 | 0.81 | MAPT (0.72) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL1327430 | 0.81 | MAPT (0.82) | MAPTLMNANPSR1HTR7HTR1A | |
| SCHEMBL10976043 | 0.81 | MAPT (0.82) | MAPTLMNANPSR1HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100262-A | MORPHOLINE RING NITROGEN IS SUBSTITUTED WITH A GROUP HAIVNG A CARBONYL FUNCTIONALITY; FAVOURABLE GASTROINTESTINAL MOTILITY STIMULATING PROPERTIES, THEY ACCELERATE GASTRIC EMPTYING | JANSSEN PHARMACEUTICA, NV. (BE) | 2000-08-08 | — | — | US | disclosed |
| EP-0827500-A1 | (2-MORPHOLINYLMETHYL)BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996037486-A1 | (2-MORPHOLINYLMETHYL)BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-11-28 | — | — | WO | disclosed |