Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 6/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.34 |
| ▸ | HTR1B | P28222 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR6 | P50406 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.32 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6041441 | 0.78 | KCNA3 (0.34) | HTR1BSLC6A4ALDH1A1KDM4E | |
| SCHEMBL8210442 | 0.75 | ENPP2 (0.32) | SLC6A4SLC6A2ENPP2 | |
| SCHEMBL8337786 | 0.70 | TSHR (0.31) | TSHR | |
| SCHEMBL6041789 | 0.68 | KCNA3 (0.34) | HTR1BMAPTSLC6A4ALDH1A1KDM4E | |
| SCHEMBL10334468 | 0.66 | MAPT (0.44) | CYP2D6MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL28534419 | 0.65 | CYP1A2 (0.57) | CYP1A2HTR2BALDH1A1HTR2AHTR2C | |
| SCHEMBL6042053 | 0.65 | KDM4E (0.35) | CYP2D6HTR1BCYP1A2SLC6A4ALDH1A1 | |
| SCHEMBL6041616 | 0.63 | L3MBTL1 (0.34) | HTR1BSLC6A4ALDH1A1KDM4E | |
| SCHEMBL8732712 | 0.63 | CYP1A2 (0.50) | CYP2D6CYP1A2ALDH1A1TSHRADRA2A | |
| SCHEMBL11057829 | 0.63 | MAPK1 (0.41) | CYP2D6CYP1A2TSHRMAPK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150526-A | Piperidine derivative having renin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |