Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.44 |
| ▸ | PDE4A | P27815 | 11/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211017 | 1.00 | PDE4D (0.44) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL8218377 | 0.99 | PDE4B (0.45) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL8218374 | 0.99 | PDE4B (0.45) | PDE4DPDE4BPDE4APDE4CPOLB | |
| Hydrochloric Acid SCHEMBL8220692 | 0.90 | NPC1 (0.40) | POLBPDGFRBPDGFRA | |
| Hydrochloric Acid SCHEMBL8220690 | 0.90 | NPC1 (0.40) | POLBPDGFRBPDGFRA | |
| Hydrochloric Acid SCHEMBL8222422 | 0.83 | KMT2A (0.38) | PDE4DPDE4BPDE4APDE4CPOLB | |
| Hydrochloric Acid SCHEMBL8222423 | 0.83 | KMT2A (0.38) | PDE4DPDE4BPDE4APDE4CPOLB | |
| Hydrochloric Acid SCHEMBL8216874 | 0.82 | ALDH1A1 (0.47) | PDE4DPDE4BPDE4APDE4CTRPC6 | |
| Hydrochloric Acid SCHEMBL8216872 | 0.82 | ALDH1A1 (0.47) | PDE4DPDE4BPDE4APDE4CTRPC6 | |
| SCHEMBL8218650 | 0.81 | PDE4A (0.41) | PDE4DPDE4BPDE4APDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046218-A | 4,5-DIMETHOXY-2-(3-OXO-3-PHENYL-1-PROPENYL)PYRIDINE USED TO CURE THE DISEASES PRODUCED BY CYTOKINE | SS PHARMACEUTICAL CO., LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0838457-A1 | NOVEL PYRIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS ACTIVE INGREDIENT | SS Pharmaceutical Co., Ltd. (JP) | 1998-04-29 | — | — | EP | disclosed |