Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214334 | 0.88 | KIF11 (0.49) | KIF11MTORABCC9ABCC8KCNJ11 | |
| SCHEMBL11925811 | 0.86 | KIF11 (0.44) | KIF11MTORKDM4EMEN1ALDH1A1 | |
| SCHEMBL8217031 | 0.85 | KIF11 (0.44) | KIF11MTORKDM4EMEN1ALDH1A1 | |
| SCHEMBL8206578 | 0.85 | PIK3CD (0.46) | KIF11KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL8217050 | 0.85 | NAMPT (0.42) | MTORPIK3CAPIK3CD | |
| SCHEMBL8217047 | 0.84 | EPHX1 (0.46) | MEN1KMT2A | |
| SCHEMBL8217184 | 0.84 | KIF11 (0.42) | KIF11KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL8213981 | 0.84 | KIF11 (0.42) | KIF11MTORKDM4EMEN1ALDH1A1 | |
| SCHEMBL8215180 | 0.83 | NAMPT (0.46) | MTORPIK3CAPIK3CDPIK3CGHTT | |
| SCHEMBL11926888 | 0.81 | KIF11 (0.43) | KIF11PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |