Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215180 | 0.90 | NAMPT (0.46) | NAMPTPIK3CAMTORPIK3CD | |
| SCHEMBL11925440 | 0.90 | CA2 (0.42) | NAMPTPIK3CAMTORPIK3CD | |
| SCHEMBL8217617 | 0.88 | PIK3CA (0.41) | NAMPTPIK3CAMTORPIK3CD | |
| SCHEMBL8213413 | 0.88 | PIK3CA (0.45) | NAMPTPIK3CAMTORPIK3CD | |
| SCHEMBL8211522 | 0.85 | KIF11 (0.44) | PIK3CAMTORPIK3CD | |
| SCHEMBL8219081 | 0.83 | NAMPT (0.43) | NAMPTPIK3CAMTORPIK3CD | |
| SCHEMBL8214174 | 0.82 | PIK3CD (0.49) | PIK3CAMTORPIK3CD | |
| SCHEMBL8213854 | 0.82 | PIK3CA (0.46) | NAMPTPIK3CAMTORPIK3CD | |
| SCHEMBL8217047 | 0.82 | EPHX1 (0.46) | NAMPT | |
| SCHEMBL8091771 | 0.81 | PIK3CD (0.51) | PIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |