Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28784289 | 0.87 | CTNNB1 (0.51) | CTNNB1SIRT2SIRT1PARP10SMN1; SMN2 | |
| SCHEMBL8954755 | 0.87 | CLCN2 (0.50) | CTNNB1CLCN2LMNAMAPTNPSR1 | |
| SCHEMBL15334091 | 0.81 | HPGD (0.41) | SIRT2SMN1; SMN2MEN1KMT2APARP1 | |
| SCHEMBL11584465 | 0.81 | LTA4H (0.47) | KMT2ALMNAMAPTNPSR1KDM4E | |
| SCHEMBL17075501 | 0.80 | PARP1 (0.44) | PARP10SMN1; SMN2MEN1KMT2APARP1 | |
| SCHEMBL288797 | 0.79 | TSHR (0.45) | PARP10MEN1KMT2APARP1NR1I2 | |
| SCHEMBL5049439 | 0.79 | CTNNB1 (0.59) | CTNNB1SIRT2SIRT1PARP10SMN1; SMN2 | |
| SCHEMBL8211656 | 0.78 | CTNNB1 (0.68) | CTNNB1SIRT2SIRT1PARP10SMN1; SMN2 | |
| SCHEMBL27991301 | 0.78 | CTNNB1 (0.57) | CTNNB1SIRT2SIRT1PARP10SMN1; SMN2 | |
| SCHEMBL27872615 | 0.78 | CTNNB1 (0.57) | CTNNB1SIRT2SIRT1PARP10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140352-A | FOR AGONIZING THE BETA 3 ADRENERGIC RECEPTOR TO TREAT TYPE II DIABETES AND OBESITY | ELI LILLY AND COMPANY (US) | 2000-10-31 | — | — | US | disclosed |
| US-6093735-A | TREATMENT OF TYPE II DIABETES AND OBESITY | ELI LILLY AND COMPANY (US) | 2000-07-25 | — | — | US | disclosed |