Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR1B | P28222 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211649 | 1.00 | HTR6 (0.53) | HTR6HTR1AHTR1BALDH1A1MAPK1 | |
| SCHEMBL8209783 | 0.91 | HTR6 (0.52) | HTR6HTR1AHTR1BALDH1A1HTR1D | |
| SCHEMBL8209786 | 0.91 | HTR6 (0.52) | HTR6HTR1AHTR1BALDH1A1HTR1D | |
| SCHEMBL8213323 | 0.87 | HTR6 (0.55) | HTR6HTR1AHTR1BALDH1A1MAPK1 | |
| SCHEMBL8213328 | 0.87 | HTR6 (0.55) | HTR6HTR1AHTR1BALDH1A1MAPK1 | |
| SCHEMBL8209082 | 0.84 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL8209078 | 0.84 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL8208579 | 0.84 | HTR6 (0.52) | HTR6HTR1AHTR1BALDH1A1 | |
| SCHEMBL8208584 | 0.84 | HTR6 (0.52) | HTR6HTR1AHTR1BALDH1A1 | |
| SCHEMBL8201987 | 0.83 | HTR6 (0.51) | HTR6HTR1AHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | claimed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | claimed |
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |