Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209078 | 1.00 | HTR6 (0.55) | HTR6HTR1AHTR1BAKR1C3AKR1C2 | |
| SCHEMBL8213323 | 0.92 | HTR6 (0.55) | HTR6HTR1AHTR1BAKR1C3AKR1C2 | |
| SCHEMBL8213328 | 0.92 | HTR6 (0.55) | HTR6HTR1AHTR1BAKR1C3AKR1C2 | |
| SCHEMBL8211087 | 0.88 | HTR6 (0.51) | HTR6HTR1AHTR1B | |
| SCHEMBL8208556 | 0.88 | HTR6 (0.51) | HTR6HTR1AHTR1B | |
| SCHEMBL8201597 | 0.86 | AKR1C3 (0.56) | HTR6HTR1AHTR1BAKR1C3AKR1C2 | |
| SCHEMBL8201592 | 0.86 | AKR1C3 (0.56) | HTR6HTR1AHTR1BAKR1C3AKR1C2 | |
| SCHEMBL8201987 | 0.86 | HTR6 (0.51) | HTR6HTR1AHTR1BHTR2A | |
| SCHEMBL8201984 | 0.86 | HTR6 (0.51) | HTR6HTR1AHTR1BHTR2A | |
| SCHEMBL8211649 | 0.84 | HTR6 (0.53) | HTR6HTR1AHTR1BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | claimed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | claimed |
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |