Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6521670 | 0.95 | ALDH1A1 (0.65) | TSHRALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL3183107 | 0.84 | TSHR (1.00) | TSHRALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL7119341 | 0.77 | MAPT (0.55) | TSHRALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL18039877 | 0.76 | MAPT (0.54) | TSHRALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL3019223 | 0.75 | ALDH1A1 (0.61) | TSHRALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL561797 | 0.75 | TP53 (0.67) | TSHRALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL1296409 | 0.74 | PPM1B (0.55) | ALDH1A1KMT2AMEN1SMN1; SMN2PKM | |
| SCHEMBL8485910 | 0.74 | PPM1B (0.55) | ALDH1A1KMT2AMEN1SMN1; SMN2PKM | |
| SCHEMBL29497130 | 0.74 | TSHR (0.78) | TSHRALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL19123323 | 0.74 | ALDH1A1 (0.59) | TSHRALDH1A1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475644-A1 | HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES | F. Hoffmann-La Roche AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011029808-A1 | HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-17 | — | — | WO | disclosed |