Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305747 | 0.86 | MAPT (0.47) | MAPTGAAHTTABCC9ABCC8 | |
| SCHEMBL15912553 | 0.83 | ALDH1A1 (0.52) | MAPTGAAHTTABCC9ABCC8 | |
| SCHEMBL1478058 | 0.79 | ALDH1A1 (0.53) | MAPTGAAHTTABCC9ABCC8 | |
| SCHEMBL1454638 | 0.78 | MAPT (0.52) | MAPTGAAHTTMEN1KMT2A | |
| SCHEMBL810604 | 0.76 | MAPT (0.50) | MAPTGAAHTTABCC9ABCC8 | |
| SCHEMBL811427 | 0.76 | HTT (0.48) | MAPTGAAHTTABCC9ABCC8 | |
| SCHEMBL5069003 | 0.75 | MAPT (0.45) | MAPTGAAHTTABCC9ABCC8 | |
| SCHEMBL1456061 | 0.75 | GSTP1 (0.52) | MAPTGAAHTTMEN1KMT2A | |
| SCHEMBL1455631 | 0.75 | MAPT (0.56) | MAPTGAAHTTMEN1KMT2A | |
| SCHEMBL810684 | 0.73 | ALDH1A1 (0.47) | MAPTGAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345652-A1 | Antiviral compounds | Abbott Laboratories (US) | 2011-07-20 | — | — | EP | disclosed |