Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213064 | 0.90 | PIK3CD (0.51) | PIK3CDPIK3CAMEN1KMT2AMAPT | |
| SCHEMBL8219760 | 0.90 | PIK3CA (0.51) | PIK3CDPIK3CAMEN1KMT2AMAPT | |
| SCHEMBL8214615 | 0.90 | KMT2A (0.49) | PIK3CDPIK3CAMEN1KMT2AMAPT | |
| SCHEMBL8217106 | 0.88 | BDKRB1 (0.47) | PIK3CDPIK3CAMEN1KMT2AMAPT | |
| SCHEMBL8212562 | 0.88 | PIK3CA (0.53) | PIK3CDPIK3CAMEN1KMT2AMAPT | |
| SCHEMBL8214218 | 0.87 | PIK3CA (0.66) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8212559 | 0.84 | MEN1 (0.46) | PIK3CDPIK3CAMEN1KMT2AMAPT | |
| SCHEMBL8213164 | 0.84 | PIK3CA (0.55) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8211601 | 0.83 | PIK3CA (0.48) | PIK3CDPIK3CAMEN1KMT2ARORC | |
| SCHEMBL8205071 | 0.82 | PIK3CA (0.54) | PIK3CDPIK3CAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |