Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.66 |
| ▸ | MTOR | P42345 | 9/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215121 | 0.91 | PIK3CA (0.56) | PIK3CAPIK3CDMTORKDR | |
| SCHEMBL8213164 | 0.89 | PIK3CA (0.55) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL8206121 | 0.89 | PIK3CA (0.62) | PIK3CAPIK3CDMTORPIK3CGKDR | |
| SCHEMBL8215045 | 0.88 | PIK3CA (0.54) | PIK3CAPIK3CDMTORKDR | |
| SCHEMBL8213955 | 0.88 | PIK3CA (0.53) | PIK3CAPIK3CDMTORKDR | |
| SCHEMBL8218937 | 0.88 | PIK3CD (0.53) | PIK3CAPIK3CDMTORPIK3CGKDR | |
| SCHEMBL8099679 | 0.88 | PIK3CD (0.52) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8212604 | 0.87 | PIK3CD (0.53) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL8205071 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3CDMTORPIK3CGKDR | |
| SCHEMBL8218782 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3CDMTORPIK3CGKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |