Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.54 |
| ▸ | MTOR | P42345 | 5/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218782 | 0.91 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPOLBLMNA | |
| SCHEMBL8216901 | 0.90 | PIK3CA (0.53) | PIK3CAMTORPIK3CDMEN1MAPT | |
| SCHEMBL8215041 | 0.90 | PIK3CA (0.66) | PIK3CAMTORPIK3CDMEN1MAPT | |
| SCHEMBL8093668 | 0.90 | POLB (0.46) | PIK3CAMTORPIK3CDPOLBALDH1A1 | |
| SCHEMBL8216858 | 0.89 | PIK3CA (0.49) | PIK3CAMTORPIK3CDPOLBMEN1 | |
| SCHEMBL8216854 | 0.89 | PIK3CA (0.52) | PIK3CAMTORPIK3CDMEN1KMT2A | |
| SCHEMBL11925465 | 0.88 | PIK3CA (0.48) | PIK3CAMTORPIK3CDALDH1A1LMNA | |
| SCHEMBL8216247 | 0.88 | CA2 (0.45) | PIK3CAMTORPIK3CDPOLBALDH1A1 | |
| SCHEMBL8214218 | 0.87 | PIK3CA (0.66) | PIK3CAMTORPIK3CDKDRPIK3CG | |
| SCHEMBL11925797 | 0.87 | PIK3CA (0.49) | PIK3CAMTORPIK3CDPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |