Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | MGLL | Q99685 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147973 | 0.82 | KDM4E (1.00) | TDP1KDM4EMGLLHSD17B10MAOB | |
| Naphthalene SCHEMBL29205373 | 0.81 | KDM4E (0.96) | TDP1KDM4EMGLLHSD17B10MAOB | |
| Dibenzofuran SCHEMBL28911883 | 0.76 | MAPT (0.38) | TDP1KDM4EMGLLHSD17B10MAOB | |
| SCHEMBL22684755 | 0.73 | KDM4E (0.79) | TDP1KDM4EMGLLHSD17B10MAOB | |
| SCHEMBL42265 | 0.73 | — | — | |
| SCHEMBL16633354 | 0.71 | KDM4E (0.77) | TDP1KDM4EMGLLHSD17B10MAOB | |
| SCHEMBL10343480 | 0.69 | KDM4E (0.71) | TDP1KDM4EMGLLHSD17B10MAOB | |
| SCHEMBL28212688 | 0.69 | MGLL (0.71) | TDP1KDM4EMGLLHSD17B10MAOB | |
| SCHEMBL8212797 | 0.68 | CA4 (0.33) | CA1CA2CYP2A6CA4CA6 | |
| SCHEMBL8166913 | 0.67 | KDM4E (0.56) | TDP1KDM4EMGLLHSD17B10MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007515-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | Abbott Laboratories (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010331-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-03-04 | — | — | WO | disclosed |