Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147974 | 0.82 | CA4 (0.37) | CA4CA6CA5ACA7ENPP2 | |
| Magnesium Chloride Anhydrous SCHEMBL20694938 | 0.76 | CA4 (0.32) | CA4CA6CA5ACA7ENPP2 | |
| Dibenzofuran SCHEMBL28911883 | 0.73 | MAPT (0.38) | CA4CA6CA5ACA7ENPP2 | |
| SCHEMBL42265 | 0.73 | — | — | |
| SCHEMBL8212792 | 0.68 | TDP1 (0.68) | CA4CA6CA5ACA7CA14 | |
| Magnesium Chloride Anhydrous SCHEMBL20694979 | 0.66 | ENPP2 (0.36) | CA4CA6CA5ACA7ENPP2 | |
| SCHEMBL19215561 | 0.60 | — | — | |
| SCHEMBL6253244 | 0.59 | MGLL (0.60) | ENPP2CYP2E1CYP2A6CYP2B6 | |
| SCHEMBL6013736 | 0.58 | HSD17B10 (0.33) | CA4CA6CA5ACA7ENPP2 | |
| Naphthalene SCHEMBL28450100 | 0.58 | ENPP2 (0.82) | CA4CA6CA5ACA7ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007515-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | Abbott Laboratories (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010331-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-03-04 | — | — | WO | disclosed |