Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8216527 | 0.89 | PIK3CD (0.37) | PIK3CDPIK3CAF10 | |
| SCHEMBL8213775 | 0.89 | PIK3CD (0.49) | PIK3CDPIK3CAABL1 | |
| SCHEMBL8214220 | 0.85 | PIK3CA (0.48) | PIK3CDPIK3CAPIP4K2APIP4K2BALDH1A1 | |
| SCHEMBL11925415 | 0.83 | MAPK1 (0.45) | PIK3CDPIK3CAABL1 | |
| SCHEMBL8218812 | 0.82 | PORCN (0.38) | PIK3CDPIK3CAF10ALDH1A1 | |
| SCHEMBL8213343 | 0.81 | PIK3R1 (0.40) | PIK3CDPIK3CA | |
| SCHEMBL8212628 | 0.79 | PIK3CA (0.35) | PIK3CDPIK3CAALDH1A1KMT2A | |
| SCHEMBL3605074 | 0.77 | PIK3CA (0.67) | PIK3CDPIK3CA | |
| SCHEMBL8204669 | 0.76 | KMT2A (0.45) | PIK3CDPIK3CAPIP4K2APIP4K2BALDH1A1 | |
| SCHEMBL8206578 | 0.76 | PIK3CD (0.46) | PIK3CDPIK3CAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |