Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213772 | 0.89 | PIK3CD (0.38) | PIK3CDPIK3CAABL1 | |
| SCHEMBL8219536 | 0.87 | PIK3CA (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL8216527 | 0.87 | PIK3CD (0.37) | PIK3CDPIK3CA | |
| SCHEMBL8214526 | 0.86 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL11925415 | 0.86 | MAPK1 (0.45) | PIK3CDPIK3CAMAPK1MAPK8MAPK9 | |
| SCHEMBL11925989 | 0.83 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGMAPK1 | |
| SCHEMBL8218812 | 0.80 | PORCN (0.38) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL8222563 | 0.80 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL8213343 | 0.78 | PIK3R1 (0.40) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3602962 | 0.78 | PIK3CA (0.80) | PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |