Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.46 |
| ▸ | GHSR | Q92847 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219563 | 0.90 | PIK3CD (0.46) | CA12CA1CA2CA9PIK3CD | |
| SCHEMBL8214220 | 0.88 | PIK3CA (0.48) | PIK3CDPIK3CAMAPT | |
| SCHEMBL11925958 | 0.86 | CA2 (0.46) | CA12CA1CA2CA9PIK3CA | |
| SCHEMBL8206578 | 0.85 | PIK3CD (0.46) | PIK3CDPIK3CAMAPTNPSR1 | |
| SCHEMBL8214526 | 0.85 | PIK3CD (0.61) | PIK3CDPIK3CAGHSR | |
| SCHEMBL8215123 | 0.84 | NAMPT (0.55) | PIK3CDPIK3CA | |
| SCHEMBL8211453 | 0.84 | CYP3A4 (0.47) | CA12CA1CA2CA9PIK3CD | |
| SCHEMBL8216529 | 0.83 | PIK3CD (0.53) | PIK3CDPIK3CAGHSRHDAC3HDAC1 | |
| SCHEMBL8214217 | 0.83 | CA12 (0.46) | CA12CA1CA2CA9PIK3CD | |
| SCHEMBL8216930 | 0.82 | PIK3CD (0.50) | CA12CA1CA2CA9PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |