Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306849 | 0.89 | ITGB3 (0.52) | CYP3A4CYP2C19AURKARPS6KB1SIRT2 | |
| SCHEMBL3929633 | 0.88 | SIRT2 (0.52) | CYP3A4CYP2C19AURKARPS6KB1CYP17A1 | |
| SCHEMBL5777563 | 0.88 | AURKA (0.51) | CYP3A4CYP2C19AURKARPS6KB1CYP17A1 | |
| SCHEMBL30844047 | 0.86 | CYP3A4 (0.50) | CYP3A4CYP2C19AURKARPS6KB1CYP17A1 | |
| SCHEMBL21583942 | 0.86 | AURKA (0.48) | CYP3A4CYP2C19AURKARPS6KB1CYP17A1 | |
| SCHEMBL13801959 | 0.86 | CYP3A4 (0.50) | CYP3A4CYP2C19AURKARPS6KB1CYP17A1 | |
| SCHEMBL7156537 | 0.86 | MGLL (0.52) | CYP3A4CYP2C19AURKARPS6KB1SIRT2 | |
| SCHEMBL13623152 | 0.86 | CYP3A4 (0.50) | CYP3A4CYP2C19AURKARPS6KB1CYP17A1 | |
| SCHEMBL27498370 | 0.86 | CYP3A4 (0.50) | CYP3A4CYP2C19AURKARPS6KB1CYP17A1 | |
| SCHEMBL10195848 | 0.86 | MAPT (0.62) | CYP3A4CYP2C19SIRT2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |