Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218892 | 0.89 | PIK3CA (0.48) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8213355 | 0.88 | EPHX1 (0.48) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8212559 | 0.85 | MEN1 (0.46) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8206186 | 0.84 | RAB9A (0.45) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8213961 | 0.83 | CA12 (0.47) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8214559 | 0.83 | EPHX2 (0.41) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8214242 | 0.83 | CYP3A4 (0.44) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8212640 | 0.82 | PIK3CA (0.51) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8214017 | 0.81 | CYP3A4 (0.43) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL8217242 | 0.81 | KDR (0.40) | CA12CA1CA2CA9RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |