Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.51 |
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213009 | 0.93 | PIK3CA (0.56) | PIK3CAPIK3CDMTORCA12CA1 | |
| SCHEMBL8205208 | 0.90 | PIK3CA (0.42) | PIK3CAPIK3CDMTORKLKB1CA12 | |
| SCHEMBL8219567 | 0.88 | PIK3CA (0.42) | PIK3CAPIK3CDMTORKLKB1CA12 | |
| SCHEMBL8206186 | 0.88 | RAB9A (0.45) | PIK3CAPIK3CDMTORCA12CA1 | |
| SCHEMBL8212559 | 0.87 | MEN1 (0.46) | PIK3CAPIK3CDMTORKLKB1CA12 | |
| SCHEMBL8219487 | 0.87 | PIK3CA (0.40) | PIK3CAPIK3CDMTORKLKB1CA12 | |
| SCHEMBL8214242 | 0.86 | CYP3A4 (0.44) | PIK3CAPIK3CDMTORCA12CA1 | |
| SCHEMBL8218892 | 0.85 | PIK3CA (0.48) | PIK3CAMTORCA12CA1CA2 | |
| SCHEMBL8211527 | 0.85 | KLKB1 (0.45) | PIK3CAMTORKLKB1EPHX1RAB9A | |
| SCHEMBL8213961 | 0.85 | CA12 (0.47) | CA12CA1CA2CA9EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |