Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPEPPS | P55786 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29092672 | 0.85 | SMN1; SMN2 (0.51) | GAASMN1; SMN2NPC1HSD17B10LMNA | |
| SCHEMBL6970729 | 0.82 | GAA (0.64) | GAASMN1; SMN2NPC1HSD17B10LMNA | |
| SCHEMBL6981446 | 0.81 | KDM4E (0.71) | GAASMN1; SMN2NPC1HSD17B10LMNA | |
| SCHEMBL6971771 | 0.80 | HTT (0.72) | GAASMN1; SMN2NPC1HSD17B10LMNA | |
| SCHEMBL6977596 | 0.79 | KDM4E (0.73) | GAASMN1; SMN2NPC1HSD17B10LMNA | |
| SCHEMBL1548586 | 0.79 | TP53 (0.62) | GAASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| SCHEMBL6973874 | 0.79 | TP53 (0.62) | GAASMN1; SMN2NPC1HSD17B10LMNA | |
| SCHEMBL12889780 | 0.79 | TP53 (0.62) | GAASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| SCHEMBL6980492 | 0.78 | TP53 (0.58) | GAASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| SCHEMBL6973438 | 0.78 | HSD17B10 (0.66) | GAASMN1; SMN2NPC1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |