Coumarin

Coumarin

SCHEMBL8214682

Cc1ccccc1C.O=c1ccc2ccccc2o1

nearest known ligand 0.80

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 6/20 0.80
CA9 Q16790 6/20 0.80
CA1 P00915 4/20 0.80
CA3 P07451 3/20 0.80
CA4 P22748 3/20 0.80
CA5A P35218 3/20 0.80
CA7 P43166 3/20 0.80
CA14 Q9ULX7 3/20 0.80
MCL1 Q07820 3/20 0.80
CA2 P00918 2/20 0.80
CA5B Q9Y2D0 2/20 0.80
CA6 P23280 2/20 0.80
TDP1 Q9NUW8 2/20 0.80
LMNA P02545 1/20 0.80
SOST Q9BQB4 1/20 0.80
ALDH1A1 P00352 4/20 0.53
PKM P14618 2/20 0.49
PGR P06401 2/20 0.49
HPGD P15428 3/20 0.46
KDM4E B2RXH2 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Coumarin SCHEMBL28886137 0.89 CA12 (1.00) CA12CA9CA1CA3CA4
Coumarin SCHEMBL3441294 0.89 CA12 (1.00) CA12CA9CA1CA3CA4
Coumarin SCHEMBL29385611 0.89 CA12 (1.00) CA12CA9CA1CA3CA4
Coumarin SCHEMBL621751 0.89 CA12 (1.00) CA12CA9CA1CA3CA4
Coumarin SCHEMBL1038138 0.89 CA12 (1.00) CA12CA9CA1CA3CA4
Coumarin SCHEMBL6252 0.89 CA12 (1.00) CA12CA9CA1CA3CA4
Coumarin SCHEMBL11101317 0.88 CA12 (0.87) CA12CA9CA1CA3CA4
Coumarin SCHEMBL1193624 0.87 CA12 (0.95) CA12CA9CA1CA3CA4
Coumarin SCHEMBL8004826 0.87 CA12 (0.95) CA12CA9CA1CA3CA4
Coumarin SCHEMBL9643642 0.87 CA12 (0.95) CA12CA9CA1CA3CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116568675-A Cyclic isothiourea derivatives as CXCR4 modulators 埃尔米乌治疗公司 2023-08-08 CN disclosed
CN-106674175-B The synthetic method of coumarin kind compound 西交利物浦大学 2019-03-26 CN disclosed
CN-106674175-A Synthesis method for coumarins compound 西交利物浦大学 2017-05-17 CN disclosed
US-6025117-A USING POLYSILANE COPOLYMER OR DENDRIMER FILM PATTERN AS MASK FOR ETCHING INSULATING OR CONDUCTING LAYER ON SUBSTRATE KABUSHIKI KAISHA TOSHIBA (JP) 2000-02-15 US disclosed
US-4349619-A CONTAINING ANTIHALATION AGENTS JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1982-09-14 US disclosed