Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.57 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.57 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.57 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.57 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3022755 | 0.86 | ABCC9 (0.69) | ABCC9ABCC8KCNJ11KCNJ8ABCC1 | |
| SCHEMBL8215039 | 0.85 | KDM4E (0.55) | ABCC1KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8222599 | 0.85 | KDM4E (0.55) | ABCC1KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8215677 | 0.84 | KDM4E (0.46) | ABCC9ABCC8KCNJ11KCNJ8ABCC1 | |
| SCHEMBL8216801 | 0.84 | CACNA1F (0.52) | ABCC1KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8214829 | 0.84 | CACNA1B (0.52) | ABCC1KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8221984 | 0.83 | ABCC1 (0.71) | ABCC1KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8224290 | 0.82 | KDM4E (0.46) | ABCC1KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8222062 | 0.82 | CACNA1F (0.54) | ABCC1TSHRPOLBGPR55CACNA1F | |
| SCHEMBL8215604 | 0.81 | ABCC1 (0.54) | ABCC1KDM4EALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | ROSKAMP RESEARCH LLC (US) | 2008-03-06 | — | — | US | disclosed |
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | APP, PSEN1, PSEN2 | ABCC9 1115/4885ABCC8 1270/4885KCNJ11 3332/4885 |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | ABCC9 382/4885ABCC8 505/4885KCNJ11 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.