Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 8/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 8/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 8/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 8/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214829 | 0.88 | CACNA1B (0.52) | CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B | |
| SCHEMBL8222062 | 0.88 | CACNA1F (0.54) | CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B | |
| SCHEMBL8215039 | 0.87 | KDM4E (0.55) | CACNA1FCACNA1DCACNA1SCACNA1CABCB1 | |
| SCHEMBL8222275 | 0.87 | ADORA3 (0.64) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL3032551 | 0.85 | CACNA1F (0.66) | CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B | |
| SCHEMBL8214827 | 0.84 | ABCC9 (0.57) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL8224290 | 0.84 | KDM4E (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CABCB1 | |
| SCHEMBL8225874 | 0.82 | CACNA1F (0.51) | CACNA1FCACNA1DCACNA1SCACNA1CABCB1 | |
| SCHEMBL8215677 | 0.82 | KDM4E (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CABCB1 | |
| SCHEMBL17367957 | 0.81 | CACNA1F (0.61) | CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | ROSKAMP RESEARCH LLC (US) | 2008-03-06 | — | — | US | disclosed |
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | APP, PSEN1, PSEN2 | CACNA1F 83/4885CACNA1D 148/4885CACNA1S 109/4885 |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | CACNA1F 40/4885CACNA1D 54/4885CACNA1S 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.