Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218182 | 0.87 | PIK3CA (0.51) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL8218786 | 0.86 | PIK3CA (0.53) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL8219760 | 0.86 | PIK3CA (0.51) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL8211599 | 0.85 | PIK3CA (0.49) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL8221081 | 0.84 | PIK3CA (0.47) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL8211601 | 0.84 | PIK3CA (0.48) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL8218892 | 0.84 | PIK3CA (0.48) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL8215437 | 0.84 | PIK3CA (0.46) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL8217566 | 0.83 | PIK3CA (0.47) | MTORPIK3CACA2CA9CA12 | |
| SCHEMBL11925678 | 0.83 | PIK3CA (0.45) | MTORPIK3CACA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |