Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.53 |
| ▸ | MTOR | P42345 | 3/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215041 | 0.88 | PIK3CA (0.66) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL8205071 | 0.87 | PIK3CA (0.54) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL8218782 | 0.87 | PIK3CA (0.54) | PIK3CAMTORPIK3CDCA2CA9 | |
| SCHEMBL8215433 | 0.86 | MTOR (0.49) | PIK3CAMTORCA12CA1CA2 | |
| SCHEMBL8216901 | 0.86 | PIK3CA (0.53) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL8215047 | 0.85 | PIK3CA (0.55) | PIK3CAMTORPIK3CDCA2MAPT | |
| SCHEMBL8216900 | 0.85 | PIK3CA (0.50) | PIK3CAMTORPIK3CDMAPTKDR | |
| SCHEMBL8216854 | 0.85 | PIK3CA (0.52) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL8103980 | 0.84 | PIK3CA (0.47) | PIK3CAMTORPIK3CDCA1CA2 | |
| SCHEMBL8214218 | 0.84 | PIK3CA (0.66) | PIK3CAMTORPIK3CDKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |