Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.46 |
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091796 | 0.84 | NPC1 (0.49) | PIK3CAMTORNPC1RAB9ALMNA | |
| SCHEMBL8218182 | 0.84 | PIK3CA (0.51) | PIK3CAMTORNPC1RAB9AADORA3 | |
| SCHEMBL8215433 | 0.84 | MTOR (0.49) | PIK3CAMTORLMNASMN1; SMN2ADORA3 | |
| SCHEMBL8219760 | 0.83 | PIK3CA (0.51) | PIK3CAMTORKMT2AMEN1CA12 | |
| SCHEMBL8211599 | 0.82 | PIK3CA (0.49) | PIK3CAMTORALDH1A1CA12CA1 | |
| SCHEMBL8211601 | 0.81 | PIK3CA (0.48) | PIK3CAMTORKMT2AMEN1CA12 | |
| SCHEMBL8218892 | 0.81 | PIK3CA (0.48) | PIK3CAMTORNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11925678 | 0.80 | PIK3CA (0.45) | PIK3CAMTORNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8217566 | 0.80 | PIK3CA (0.47) | PIK3CAMTORLMNAKMT2AMEN1 | |
| SCHEMBL8083683 | 0.80 | NPC1 (0.42) | PIK3CAMTORNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |