SCHEMBL8215575

SCHEMBL8215575

CCCCC1=C([Si](C)(C)Nc2ccccc2)CC=C1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.33
KCNH3 Q9ULD8 1/20 0.32
PDE4A P27815 1/20 0.32
PDE4B Q07343 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32
PDE3B Q13370 1/20 0.32
PDE3A Q14432 1/20 0.32
ORAI1 Q96D31 1/20 0.31
ORAI2 Q96SN7 1/20 0.31
ORAI3 Q9BRQ5 1/20 0.31
TRPV6 Q9H1D0 1/20 0.31
ALDH1A1 P00352 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8214923 0.96 KCNH3 (0.37) KCNH3ALDH1A1NPSR1
SCHEMBL8207040 0.95 KCNH3 (0.36) KCNH3ALDH1A1NPSR1
SCHEMBL8207979 0.95 KCNH3 (0.36) KCNH3ALDH1A1NPSR1
SCHEMBL8216375 0.85 TRPV1 (0.32) TRPV1KCNH3PDE4APDE4BPDE4C
SCHEMBL8215558 0.84 TRPV1 (0.32) TRPV1KCNH3PDE4APDE4BPDE4C
SCHEMBL8216335 0.82 KCNH3 (0.35) KCNH3ALDH1A1NPSR1
SCHEMBL8208020 0.80 KCNH3 (0.35) KCNH3ALDH1A1NPSR1
SCHEMBL8218873 0.79 KCNH3 (0.35) KCNH3ALDH1A1NPSR1
SCHEMBL8207977 0.79 KCNH3 (0.35) KCNH3ALDH1A1NPSR1
SCHEMBL8153292 0.79 MEN1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136995-A Process for producing aminosilane compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-10-24 US disclosed