SCHEMBL8208020

SCHEMBL8208020

CCCCCC1=C([Si](Nc2ccccc2)(c2ccccc2)c2ccccc2)CC=C1

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KCNH3 Q9ULD8 1/20 0.35
HTT P42858 2/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
XBP1 P17861 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
HSD17B10 Q99714 1/20 0.33
SIGMAR1 Q99720 1/20 0.31
DHFR P00374 1/20 0.30
EPHX1 P07099 3/20 0.30
ALDH1A1 P00352 1/20 0.30
GPR84 Q9NQS5 1/20 0.30
HTR2A P28223 1/20 0.30
DNM1 Q05193 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8207977 0.99 KCNH3 (0.35) KCNH3HTTLMNAMAPTXBP1
SCHEMBL8218873 0.99 KCNH3 (0.35) KCNH3HTTLMNAMAPTXBP1
SCHEMBL8215558 0.96 TRPV1 (0.32) KCNH3
SCHEMBL8216335 0.86 KCNH3 (0.35) KCNH3HTTLMNAMAPTXBP1
SCHEMBL8220095 0.85 GPR84 (0.33) KCNH3SIGMAR1DHFRGPR84HTR2A
SCHEMBL8214923 0.84 KCNH3 (0.37) KCNH3HTTLMNAMAPTXBP1
SCHEMBL8216356 0.84 DHFR (0.32) HTTSMN1; SMN2DHFRALDH1A1GPR84
SCHEMBL8216453 0.84 DHFR (0.32) HTTSMN1; SMN2DHFRALDH1A1GPR84
SCHEMBL8215717 0.84 SIGMAR1 (0.30) SIGMAR1
SCHEMBL8207040 0.83 KCNH3 (0.36) KCNH3HTTLMNAMAPTXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136995-A Process for producing aminosilane compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-10-24 US disclosed