Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215786 | 0.84 | TSHR (0.53) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL348272 | 0.82 | TSHR (0.59) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL25932256 | 0.75 | TDP1 (0.51) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL5951526 | 0.75 | TDP1 (0.51) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL11219818 | 0.74 | TSHR (0.59) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL30578459 | 0.74 | TSHR (0.59) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL31327401 | 0.74 | MAPT (0.61) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL30443281 | 0.74 | MAPT (0.66) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL976044 | 0.74 | MAPT (0.61) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL719267 | 0.74 | MAPT (0.66) | MAPTTSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019720-A1 | COMBINATORIAL PROCESS FOR PREPARING TETRAHYDROQUINOLINE LIBRARIES | ELI LILLY AND COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998027427-A1 | COMBINATORIAL PROCESS FOR PREPARING TETRAHYDROQUINOLINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |