Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31327401 | 1.00 | MAPT (0.61) | MAPTTSHRMEN1ALDH1A1POLB | |
| SCHEMBL30443281 | 0.85 | MAPT (0.66) | MAPTTSHRMEN1ALDH1A1POLB | |
| SCHEMBL719267 | 0.85 | MAPT (0.66) | MAPTTSHRMEN1ALDH1A1POLB | |
| SCHEMBL31361989 | 0.82 | MAPT (0.72) | MAPTTSHRALDH1A1TDP1CYP3A4 | |
| SCHEMBL11744519 | 0.82 | TSHR (0.51) | MAPTTSHRMEN1ALDH1A1POLB | |
| SCHEMBL30706306 | 0.82 | LMNA (0.55) | MAPTTSHRMEN1ALDH1A1POLB | |
| SCHEMBL2038302 | 0.79 | MAPT (0.73) | MAPTTSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL19427142 | 0.79 | MAPT (0.52) | MAPTTSHRMEN1ALDH1A1POLB | |
| SCHEMBL1913458 | 0.78 | TSHR (0.51) | MAPTTSHRMEN1ALDH1A1POLB | |
| SCHEMBL22115093 | 0.78 | TSHR (0.51) | MAPTTSHRMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791121-B1 | BENZISOTHIAZOL-3(1H)-ONE-5-SULFONYL DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2016-08-03 | — | — | EP | disclosed |
| US-8815895-B2 | Mediators of hedgehog signaling pathways, compositions and uses related hereto | CURIS, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815895-B2 | Mediators of hedgehog signaling pathways, compositions and uses related hereto | CURIS, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| EP-1807074-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2013-10-23 | — | — | EP | disclosed |
| US-8524745-B2 | Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators | ALLERGAN, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20130150413-A1 | BENZISOTHIAZOL-3(1H)-ONE-5-SULFONYL DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-8440830-B2 | Tetrahydro-fused pyridines as histone deacetylase inhibitors | 4SC AG (DE) | 2013-05-14 | — | — | US | disclosed |
| EP-2197552-B1 | NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2012-11-21 | — | — | EP | disclosed |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | CURIS, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | CURIS, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| EP-1888579-A2 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | Aventis Pharma S.A. (FR) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006123061-A2 | FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2006-11-23 | — | — | WO | disclosed |
| US-20050288324-A1 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | BLUME THORSTEN | 2005-12-29 | — | — | US | disclosed |
| US-6946466-B2 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | SCHERING AG (DE) | 2005-09-20 | — | — | US | disclosed |
| WO-2004089882-A2 | AROMATIC SULFONAMIDES AS PEROXYNITRITE-REARRANGEMENT CATALYSTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-10-21 | — | — | WO | disclosed |
| US-20040204452-A1 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | SCHERING AG (DE) | 2004-10-14 | — | — | US | disclosed |
| US-5529583-A | HAIR DYE | CLAIROL INCORPORATED (US) | 1996-06-25 | — | — | US | disclosed |
| EP-0635483-A1 | Process for preparing nitroaniline derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1995-01-25 | — | — | EP | disclosed |
| EP-0145513-B1 | DERIVATIVES OF DIMETHYL-3-NITRO-4-AMINO-ANILINE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE DYEING OF KERATIN FIBRES | L'OREAL (FR) | 1988-03-23 | — | — | EP | disclosed |
| EP-0145513-A2 | Derivatives of dimethyl-3-nitro-4-amino-aniline, process for their preparation and their use in the dyeing of keratin fibres | L'OREAL (FR) | 1985-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288324-A1 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | SQOR, GSR, PPOX | MAPT 2502/4885TSHR 891/4885MEN1 4727/4885 |
| US-20040204452-A1 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | SQOR, NOX1, GSR | MAPT 2315/4885TSHR 969/4885MEN1 4545/4885 |
| US-20130150413-A1 | BENZISOTHIAZOL-3(1H)-ONE-5-SULFONYL DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | CCR5, CCR2, CX3CR1 | MAPT 4339/4885TSHR 676/4885MEN1 4521/4885 |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | SHH, SMO, GLI1 | MAPT 4728/4885TSHR 553/4885MEN1 1166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.