Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29742542 | 0.76 | CDC7 (0.39) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL15051861 | 0.76 | CDC7 (0.39) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL31712942 | 0.75 | ALDH1A1 (0.44) | HTR2AHTR2C | |
| SCHEMBL15291748 | 0.75 | ALDH1A1 (0.44) | HTR2AHTR2C | |
| SCHEMBL29569821 | 0.72 | CLK1 (0.54) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL672509 | 0.72 | CLK1 (0.54) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL29137654 | 0.70 | EGFR (0.30) | — | |
| SCHEMBL13154633 | 0.69 | NOTUM (0.42) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL13154654 | 0.69 | CHRNB2 (0.43) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL1300267 | 0.68 | EGFR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008597-A1 | DIHYDROIMIDAZOISOQUINOLINE DERIVATIVES USEFUL AS PDE10 INHIBITORS | SCHERING CORPORATION (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2011008597-A1 | DIHYDROIMIDAZOISOQUINOLINE DERIVATIVES USEFUL AS PDE10 INHIBITORS | SCHERING CORPORATION (US) | 2011-01-20 | — | — | WO | disclosed |
| EP-0341213-B1 | 5-Aryl-substituted-2,3-dihydro-imidazo [1,2-a]furo[3,2-c]- or thieno[2,3-c]pyridines | SANDOZ AG (CH) | 1995-02-22 | — | — | EP | disclosed |
| US-5141932-A | Antitumor agents | SANDOZ PHARMACEUTICALS CORP. (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0258175-B1 | 5-hetero- or aryl-substituted-imidazo[2,1-a]isoquinolines | SANDOZ AG (CH) | 1992-04-01 | — | — | EP | disclosed |
| US-4992428-A | Hypotensive agents, antiallergens, bronchodilator | SANDOZ PHARM. CORP. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4910206-A | Endotoxin induced lung injury | SANDOZ PHARMACEUTICALS CORP. (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0341213-A2 | 5-Aryl-substituted-2,3-dihydro-imidazo [1,2-a]furo[3,2-c]- or thieno[2,3-c]pyridines | SANDOZ AG (CH) | 1989-11-08 | — | — | EP | disclosed |
| WO-1988006157-A1 | 5-HETERO- OR ARYL-SUBSTITUTED-IMIDAZO[2,1-a]ISOQUINOLINES | SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. (AT) | 1988-08-25 | — | — | WO | disclosed |
| EP-0258175-A2 | 5-hetero- or aryl-substituted-imidazo[2,1-a]isoquinolines | SANDOZ AG (CH) | 1988-03-02 | — | — | EP | disclosed |
| US-3887566-A | 2,3-Dihydroimidazo-isoquinolines | ASPRO NICHOLAS LTD | 1975-06-03 | — | — | US | disclosed |