Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.47 |
| ▸ | PYGL | P06737 | 9/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL7793179 | 0.86 | ALDH1A1 (0.50) | ALDH1A1GRIK1GRIK2PYGLALDH1A3 | |
| SCHEMBL29364412 | 0.82 | ALDH1A1 (1.00) | ALDH1A1PYGLVCAM1ALDH1A3ALDH3A1 | |
| SCHEMBL48577 | 0.82 | ALDH1A1 (1.00) | ALDH1A1PYGLVCAM1ALDH1A3ALDH3A1 | |
| Methylene Chloride SCHEMBL27781502 | 0.81 | ALDH1A1 (0.86) | ALDH1A1GRIK1GRIK2PYGLVCAM1 | |
| Hydrochloric Acid SCHEMBL28849470 | 0.80 | ALDH1A1 (0.95) | ALDH1A1PYGLVCAM1ALDH1A3ALDH3A1 | |
| Hydrochloric Acid SCHEMBL28849465 | 0.78 | ALDH1A1 (0.91) | ALDH1A1PYGLVCAM1ALDH1A3ALDH3A1 | |
| Glycine SCHEMBL27996666 | 0.77 | CYP1A2 (0.50) | ALDH1A1GRIK1GRIK2KMT2A | |
| SCHEMBL14616919 | 0.75 | ALDH1A1 (0.52) | ALDH1A1VCAM1ALDH1A3ALDH3A1 | |
| SCHEMBL29080593 | 0.75 | ALDH1A1 (0.83) | ALDH1A1PYGLVCAM1ALDH1A3ALDH3A1 | |
| Glycine SCHEMBL6988617 | 0.74 | TSHR (0.44) | KMOTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121054-A | DIVIDING FLUIDS AND PRECIPITATES; POSITIONING MULTICOMPARTMENT VESSELS ON SUPPORTS, SPINNING A CENTRIFUGE, ALLOWING PRECIPITATES TO SEDIMENT INTO VESSELS, EXCESS FLUIDS WILL BE EJECTED FROM THE TOP OF THE VESSEL | TREGA BIOSCIENCES, INC. (US) | 2000-09-19 | — | — | US | disclosed |