Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | DBH | P09172 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27944822 | 0.82 | ALDH1A1 (0.50) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL27700003 | 0.82 | ALDH1A1 (0.50) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL28191937 | 0.80 | HDAC8 (0.49) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL1244069 | 0.80 | HDAC8 (0.53) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL3195611 | 0.80 | HDAC8 (0.49) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| Iodomethane SCHEMBL7678454 | 0.77 | ALDH1A1 (0.47) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL7675436 | 0.76 | ALDH1A1 (0.50) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL12951910 | 0.76 | AKR1B1 (0.50) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL7674447 | 0.76 | HDAC8 (0.45) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9767009 | 0.74 | SIGMAR1 (0.52) | HDAC8HDAC6ALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005456-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-10 | — | — | WO | disclosed |