Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 3/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16151917 | 0.91 | AKT1 (0.40) | AKT1AKT2AKT3CCR5NTSR1 | |
| SCHEMBL683587 | 0.91 | AKT1 (0.40) | AKT1AKT2AKT3CCR5NTSR1 | |
| SCHEMBL20282847 | 0.89 | AKT1 (0.39) | AKT1AKT2AKT3CCR5DPP4 | |
| SCHEMBL22622536 | 0.89 | AKT1 (0.39) | AKT1AKT2AKT3CCR5DPP4 | |
| SCHEMBL681463 | 0.89 | AKT1 (0.39) | AKT1AKT2AKT3CCR5DPP4 | |
| SCHEMBL2738749 | 0.85 | CCR5 (0.46) | AKT1AKT2AKT3CCR5NTSR1 | |
| SCHEMBL2738657 | 0.85 | CCR5 (0.46) | AKT1AKT2AKT3CCR5NTSR1 | |
| SCHEMBL2738656 | 0.85 | CCR5 (0.46) | AKT1AKT2AKT3CCR5NTSR1 | |
| SCHEMBL17424881 | 0.85 | DPP7 (0.43) | AKT1AKT2AKT3DPP4DPP7 | |
| SCHEMBL2738622 | 0.82 | CCR5 (0.43) | AKT1AKT2AKT3CCR5NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |