Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 9/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738656 | 1.00 | CCR5 (0.46) | CCR5MCHR1MALT1NTSR1AKT1 | |
| SCHEMBL2738749 | 1.00 | CCR5 (0.46) | CCR5MCHR1MALT1NTSR1AKT1 | |
| SCHEMBL2738755 | 0.93 | CCR5 (0.43) | CCR5NTSR1AKT1AKT2AKT3 | |
| SCHEMBL2738622 | 0.93 | CCR5 (0.43) | CCR5NTSR1AKT1AKT2AKT3 | |
| SCHEMBL12188575 | 0.89 | CCR5 (0.47) | CCR5MCHR1MALT1NTSR1AKT1 | |
| SCHEMBL12188488 | 0.89 | CCR5 (0.47) | CCR5MCHR1MALT1NTSR1AKT1 | |
| SCHEMBL680138 | 0.87 | CCR5 (0.45) | CCR5MCHR1MALT1 | |
| SCHEMBL679660 | 0.87 | CCR5 (0.45) | CCR5MCHR1MALT1 | |
| SCHEMBL8217390 | 0.85 | AKT1 (0.40) | CCR5NTSR1AKT1AKT2AKT3 | |
| SCHEMBL2738488 | 0.83 | OPRK1 (0.43) | CCR5NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966065-A2 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |