Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214146 | 0.85 | NUDT14 (0.50) | KDM4EALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL8205966 | 0.84 | KMT2A (0.48) | KDM4EALDH1A1L3MBTL1NPSR1TDP1 | |
| SCHEMBL3277198 | 0.84 | KDM4E (0.51) | KDM4EL3MBTL1RAB9ANPC1MEN1 | |
| SCHEMBL14298815 | 0.84 | MEN1 (0.45) | KDM4EALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL8213977 | 0.82 | LMNA (0.51) | KDM4EALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL13510724 | 0.82 | KDM4E (0.57) | KDM4EALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL13509150 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL8219599 | 0.80 | FLT3 (0.49) | KDM4EALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL8207607 | 0.79 | PDE10A (0.54) | KDM4EALDH1A1L3MBTL1LMNATDP1 | |
| SCHEMBL8215862 | 0.78 | KDR (0.48) | KDM4ELMNANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021960-A2 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |