Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 4/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | LGMN | Q99538 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1110166 | 0.78 | CYP2C19 (0.42) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL4573322 | 0.76 | MAPT (0.36) | ALDH1A1SMN1; SMN2MAPTLMNANPC1 | |
| SCHEMBL8206759 | 0.75 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL12615095 | 0.71 | HRH4 (0.47) | ALDH1A1KDM4E | |
| SCHEMBL8193074 | 0.70 | LMNA (0.33) | LMNA | |
| SCHEMBL13335285 | 0.69 | AKR1C3 (0.51) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL2450416 | 0.69 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL609770 | 0.69 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL3161270 | 0.68 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL24837941 | 0.67 | KDM4E (0.46) | ALDH1A1SMN1; SMN2MAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | claimed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |