Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.53 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.49 |
| ▸ | ABAT | P80404 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL7798563 | 0.88 | ALDH1A1 (0.42) | ALDH1A1TSHRAOX1FDPSHPGD | |
| SCHEMBL493442 | 0.85 | ALDH1A1 (0.70) | ALDH1A1TSHRAOX1FDPSHPGD | |
| SCHEMBL349392 | 0.78 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL19849522 | 0.76 | ALDH1A1 (0.55) | ALDH1A1TSHRAOX1FDPSHPGD | |
| Cyclohexylamine SCHEMBL8025661 | 0.76 | GRIK1 (0.40) | ALDH1A1TSHRAOX1FDPSHPGD | |
| SCHEMBL7530242 | 0.76 | ALDH1A1 (0.53) | ALDH1A1TSHRAOX1FDPSHPGD | |
| SCHEMBL27869198 | 0.76 | ALDH1A1 (0.62) | ALDH1A1TSHRAOX1FDPSHPGD | |
| SCHEMBL13956393 | 0.76 | POLB (0.49) | ALDH1A1FDPSHPGDSMN1; SMN2POLB | |
| Anisaldehyde SCHEMBL7798026 | 0.76 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL30285852 | 0.75 | HSD17B10 (0.64) | ALDH1A1TSHRAOX1FDPSHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121054-A | DIVIDING FLUIDS AND PRECIPITATES; POSITIONING MULTICOMPARTMENT VESSELS ON SUPPORTS, SPINNING A CENTRIFUGE, ALLOWING PRECIPITATES TO SEDIMENT INTO VESSELS, EXCESS FLUIDS WILL BE EJECTED FROM THE TOP OF THE VESSEL | TREGA BIOSCIENCES, INC. (US) | 2000-09-19 | — | — | US | disclosed |