SCHEMBL8218522

SCHEMBL8218522

CCCCCC1CCC(c2ccc(-c3ccc(C4CCC(COC)CC4)cc3F)c(F)c2)CC1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.35
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
MAPT P10636 2/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
MAPK1 P28482 1/20 0.34
GAA P10253 1/20 0.34
SPHK1 Q9NYA1 3/20 0.33
S1PR1 P21453 5/20 0.33
SGPL1 O95470 1/20 0.33
S1PR4 O95977 1/20 0.32
S1PR5 Q9H228 1/20 0.32
OPRL1 P41146 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C8 P10632 1/20 0.32
S1PR3 Q99500 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8220318 0.93 CYP3A4 (0.39) CYP2C9MEN1KMT2AMAPTALDH1A1
SCHEMBL8214999 0.92 SPHK1 (0.41) CYP2C9SPHK1CYP3A4CYP2C8S1PR3
SCHEMBL8216791 0.92 SPHK1 (0.36) CYP2C9SPHK1CYP3A4CYP2C8S1PR3
SCHEMBL8217737 0.91 CYP2C9 (0.43) CYP2C9MEN1KMT2AMAPTALDH1A1
SCHEMBL11117883 0.91 CYP2C9 (0.40) CYP2C9MEN1KMT2AMAPTALDH1A1
SCHEMBL11117880 0.91 CYP2C9 (0.40) CYP2C9MEN1KMT2AMAPTALDH1A1
SCHEMBL11117177 0.90 SPHK1 (0.40) CYP2C9MEN1KMT2AMAPTALDH1A1
SCHEMBL11117176 0.90 SPHK1 (0.40) CYP2C9MEN1KMT2AMAPTALDH1A1
SCHEMBL8216136 0.90 CYP2C9 (0.39) CYP2C9MEN1KMT2AMAPTALDH1A1
SCHEMBL8214955 0.89 OPRL1 (0.33) CYP2C9MEN1KMT2AOPRL1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6117361-A FOUR RING COMPOUND HAVING AN ALKYL GROUP SUBSTITUTED WITH ONE OR MORE ETHERS, AND A HALOGEN ATOM SUBSTITUTED BENZENE RING; BROAD TEMPERATURE RANGE OF NEMATIC PHASE, HIGHER MISCIBILITY WITH OTHER LIQUID CRYSTAL COMPOUNDS, AND CHEMICAL STABILITY CHISSO CORP. (JP) 2000-09-12 US disclosed
EP-0891961-A1 LIQUID CRYSTAL COMPOUNDS HAVING FLUORINATED 1,4-PHENYLENE SKELETONS, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORPORATION (JP) 1999-01-20 EP disclosed