Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 14/20 | 0.70 |
| ▸ | CTSS | P25774 | 14/20 | 0.70 |
| ▸ | CTSK | P43235 | 14/20 | 0.70 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8226527 | 0.94 | CTSB (0.79) | CTSBCTSSCTSKOPRL1POLB | |
| SCHEMBL8223388 | 0.93 | CTSB (0.70) | CTSBCTSSCTSKPOLB | |
| SCHEMBL11917607 | 0.92 | CTSB (0.60) | CTSBCTSSCTSKOPRL1 | |
| SCHEMBL8217484 | 0.89 | CTSB (0.64) | CTSBCTSSCTSKOPRL1POLB | |
| SCHEMBL347010 | 0.88 | CTSB (0.89) | CTSBCTSSCTSK | |
| SCHEMBL347518 | 0.86 | CTSS (0.70) | CTSBCTSSCTSKOPRL1 | |
| SCHEMBL12237384 | 0.86 | CTSB (0.66) | CTSBCTSSCTSKOPRL1HRH3 | |
| SCHEMBL8224236 | 0.85 | CTSS (0.76) | CTSBCTSSCTSKPOLB | |
| SCHEMBL8225355 | 0.84 | CTSB (0.67) | CTSBCTSSCTSKHRH3 | |
| SCHEMBL347417 | 0.82 | CTSB (1.00) | CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |