Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.51 |
| ▸ | PDE4A | P27815 | 6/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218600 | 1.00 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DNPC1 | |
| SCHEMBL8219212 | 0.86 | NPC1 (0.60) | NPC1MAPTRAB9ALMNABCHE | |
| SCHEMBL8219209 | 0.86 | NPC1 (0.60) | NPC1MAPTRAB9ALMNABCHE | |
| SCHEMBL8218377 | 0.82 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8218374 | 0.82 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7447179 | 0.81 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DNPC1 | |
| SCHEMBL8211017 | 0.81 | PDE4D (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8211014 | 0.81 | PDE4D (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7447175 | 0.81 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DNPC1 | |
| SCHEMBL8218801 | 0.81 | NPC1 (0.51) | NPC1MAPTRAB9ALMNABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046218-A | 4,5-DIMETHOXY-2-(3-OXO-3-PHENYL-1-PROPENYL)PYRIDINE USED TO CURE THE DISEASES PRODUCED BY CYTOKINE | SS PHARMACEUTICAL CO., LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0838457-A1 | NOVEL PYRIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS ACTIVE INGREDIENT | SS Pharmaceutical Co., Ltd. (JP) | 1998-04-29 | — | — | EP | disclosed |