SCHEMBL8218672

SCHEMBL8218672

FC1(c2ccccc2)OCCOO1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.36
MAOA P21397 4/20 0.36
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CYP1A2 P05177 1/20 0.32
HTR2A P28223 2/20 0.31
HTR2C P28335 2/20 0.31
HTR2B P41595 2/20 0.31
CHRM2 P08172 1/20 0.30
CHRM4 P08173 1/20 0.30
CHRM1 P11229 1/20 0.30
CHRM3 P20309 1/20 0.30
SIGMAR1 Q99720 1/20 0.30
HDAC1 Q13547 1/20 0.30
HDAC2 Q92769 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27514263 0.68 MAOB (0.40) MAOBMAOAHTR2AHTR2CHTR2B
SCHEMBL6919085 0.68 TSHR (0.33) TSHRMAPK1SMN1; SMN2L3MBTL1CHRM2
SCHEMBL19417838 0.67 CYP1A2 (0.36) MAOBMAOATSHRMAPK1SMN1; SMN2
SCHEMBL17146580 0.66 CYP1A2 (0.38) MAOBMAOATSHRMAPK1SMN1; SMN2
SCHEMBL1256099 0.66 CHEK2 (0.39) MAOBMAOATSHRMAPK1SMN1; SMN2
SCHEMBL27825774 0.64 CHEK2 (0.38) MAOBMAOATSHRMAPK1SMN1; SMN2
SCHEMBL29478279 0.64 MAOB (0.44) MAOBMAOAHTR2AHTR2CHTR2B
SCHEMBL2642364 0.64 MEN1 (0.39) MAOBMAOAHTR2A
SCHEMBL27514264 0.63 MAOB (0.35) MAOBMAOA
SCHEMBL11616219 0.63 CYP1A2 (0.44) MAOBMAOATSHRMAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000059501-A1 WATER-SOLUBLE TRIOXANES AS POTENT AND SAFE ANTIMALARIAL AGENTS JOHNS HOPKINS UNIVERSITY (US) 2000-10-12 WO disclosed