Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123806 | 0.87 | DPP4 (0.35) | OPRM1OPRK1OPRL1PNMTMAOA | |
| SCHEMBL2360103 | 0.73 | OPRM1 (0.41) | MEN1CYP2C9KMT2AOPRM1OPRK1 | |
| SCHEMBL31279992 | 0.73 | GRIN1 (0.40) | OPRM1OPRK1OPRL1PNMTMAOA | |
| SCHEMBL27728282 | 0.71 | CYP1A2 (0.38) | MEN1CYP2C9KMT2AOPRM1OPRK1 | |
| SCHEMBL9723553 | 0.70 | OPRM1 (0.42) | MEN1CYP2C9KMT2AOPRM1OPRK1 | |
| SCHEMBL8016354 | 0.70 | ALDH1A1 (0.36) | CYP2C9OPRM1OPRK1OPRL1PNMT | |
| SCHEMBL1569110 | 0.68 | DPP4 (0.38) | OPRM1OPRK1OPRL1PNMTMAOA | |
| SCHEMBL1322736 | 0.67 | CHRM2 (0.46) | OPRM1OPRK1OPRL1GRIN1GRIN2A | |
| SCHEMBL28061487 | 0.67 | HSD11B1 (0.38) | OPRM1OPRK1OPRL1DPP4 | |
| SCHEMBL27514264 | 0.67 | MAOB (0.35) | MEN1CYP2C9KMT2AOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0875247-B1 | Method for controlling the plasma level of lipoproteins | TNO (NL) | 2003-05-28 | — | — | EP | claimed |
| EP-0875247-A1 | Method for controlling the plasma level of lipoproteins | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1998-11-04 | — | — | EP | claimed |
| EP-1501815-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003095438-A9 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-12-23 | — | — | WO | disclosed |
| WO-2003095438-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-20 | — | — | WO | disclosed |
| EP-0875247-B1 | Method for controlling the plasma level of lipoproteins | TNO (NL) | 2003-05-28 | — | — | EP | disclosed |
| US-6444664-B1 | ANTAGONIST OF PLATELET ACTIVATING FACTOR; BENZO- OR THIENOTRIAZOLO-DIAZEPINE OR BENZODIAZEPINE DERIVATIVE | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST - NATUURWETEN SCHAPPELIJK ONDERZOEK (TNO) (NL) | 2002-09-03 | — | — | US | disclosed |
| US-6444664-B1 | ANTAGONIST OF PLATELET ACTIVATING FACTOR; BENZO- OR THIENOTRIAZOLO-DIAZEPINE OR BENZODIAZEPINE DERIVATIVE | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST - NATUURWETEN SCHAPPELIJK ONDERZOEK (TNO) (NL) | 2002-09-03 | — | — | US | disclosed |
| EP-0875247-A1 | Method for controlling the plasma level of lipoproteins | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1998-11-04 | — | — | EP | disclosed |
| EP-0875247-A1 | Method for controlling the plasma level of lipoproteins | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1998-11-04 | — | — | EP | disclosed |