Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 13/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9092974 | 0.72 | HIF1A (0.46) | HIF1AEPAS1 | |
| SCHEMBL8216793 | 0.72 | NISCH (0.49) | NISCH | |
| SCHEMBL9092213 | 0.69 | HIF1A (0.44) | HIF1AEPAS1 | |
| SCHEMBL6984727 | 0.69 | RAB9A (0.41) | HIF1AEPAS1 | |
| SCHEMBL9091985 | 0.68 | HIF1A (0.45) | HIF1AEPAS1 | |
| SCHEMBL5476725 | 0.67 | NISCH (0.79) | NISCHTOP2ATOP2BHTR1DADRA1A | |
| SCHEMBL7738844 | 0.67 | HIF1A (0.58) | HIF1AEPAS1 | |
| SCHEMBL9092543 | 0.67 | HIF1A (0.44) | HIF1AEPAS1 | |
| SCHEMBL13135587 | 0.66 | NISCH (0.86) | NISCH | |
| SCHEMBL6024450 | 0.66 | HTR2C (0.54) | HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000078724-A2 | IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |